Variant Effect Prediction from a dbSNP rs ID: Consequence, SIFT, PolyPhen (Ensembl VEP)

ensembl/variant-effect-by-rsid

Predicts the consequences of one known genetic variant named by its dbSNP rs ID (for example rs56116432) using the Ensembl Variant Effect Predictor: most severe consequence, and for each affected transcript the gene, impact, amino-acid change, codons and SIFT and PolyPhen predictions, plus known co-located variants. A variant with several genomic placements returns one result for each. Default annotation only; no third-party plugin scores. An rs ID that does not exist returns a validation error. Ensembl data, passed through unmodified and served by Eden Engine; not an official Ensembl product.

activeper callv1

Price

$0.0026 per call

You pay the price shown. If a call turns out to cost more than its quote, you pay the actual price, capped at twice the quote. No monthly minimum. Top-ups start at $5.

Data source

Ensembl

Source: Ensembl (EMBL-EBI), https://www.ensembl.org, retrieved through the Ensembl REST API. Served by Eden Engine; not an official Ensembl product.

Use it

Five steps: search, inspect, learn, run, settle. No per-tool setup; your agent reaches this tool through the meta-tools it already has.

Connect once and your AI can find and run this tool, and any other it needs.

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agent

// 1. search: find the tool
omnial_search({ query: "what you need" })

// 2. inspect: price and input schema
omnial_inspect({ tool: "ensembl/variant-effect-by-rsid" })

// 3. learn: read the usage guide at runtime
omnial_learn({ tool: "ensembl/variant-effect-by-rsid" })

// 4. run: price the exact call first, then run it
omnial_execute({ tool: "ensembl/variant-effect-by-rsid", input: { /* see input_schema */ }, dry_run: true })
omnial_execute({ tool: "ensembl/variant-effect-by-rsid", input: { /* ... */ } })

// 5. settle: the call is charged when it finishes, nothing to do

Not connected yet? Point your MCP client at https://mcp.eden-engine.com/mcp, then copy a config for your client.

Pricing

Every charge this tool can incur.

Charge	Price
Per call	$0.0026

Updated: Oct 20, 2026

Input and output schemas

Input schema

input_schema.json

{
  "type": "object",
  "required": [
    "rsid"
  ],
  "properties": {
    "rsid": {
      "type": "string",
      "pattern": "^rs[0-9]{1,15}$",
      "description": "A dbSNP rs ID: rs followed by digits, for example rs56116432 or rs699."
    },
    "species": {
      "type": "string",
      "default": "human",
      "pattern": "^[a-z][a-z0-9_]{1,59}$",
      "description": "Ensembl species name or alias, lowercase, for example human or homo_sapiens. Defaults to human."
    }
  },
  "additionalProperties": false
}

Output schema

output_schema.json

{
  "type": "object",
  "required": [
    "results"
  ],
  "properties": {
    "results": {
      "type": "array",
      "items": {
        "type": "object",
        "properties": {
          "id": {
            "type": "string",
            "description": "The submitted rs ID."
          },
          "end": {
            "type": "integer"
          },
          "input": {
            "type": "string",
            "description": "The submitted rs ID, echoed."
          },
          "start": {
            "type": "integer"
          },
          "strand": {
            "type": "integer"
          },
          "allele_string": {
            "type": "string",
            "description": "Reference and alternate allele, e.g. A/G."
          },
          "assembly_name": {
            "type": "string"
          },
          "seq_region_name": {
            "type": "string"
          },
          "colocated_variants": {
            "type": "array",
            "items": {
              "type": "object",
              "additionalProperties": true
            },
            "description": "Known variants at the same position, with ids and population frequencies."
          },
          "most_severe_consequence": {
            "type": "string",
            "description": "The most severe Sequence Ontology term, for example missense_variant."
          },
          "transcript_consequences": {
            "type": "array",
            "items": {
              "type": "object",
              "additionalProperties": true
            },
            "description": "One entry per affected transcript: gene_id, gene_symbol, transcript_id, consequence_terms, impact, amino_acids, codons, sift_prediction and sift_score, polyphen_prediction and polyphen_score where the service computes them."
          }
        },
        "additionalProperties": true
      }
    }
  },
  "description": "One VEP result per genomic placement of the variant."
}