OMA Orthologs of a Protein Across Species (OMA Browser)

omabrowser/orthologs

Lists the orthologs of one protein in other species from the OMA Browser, filtered to one relation type: 1:1, 1:n, m:1 or m:n. Each ortholog has its species, OMA id, canonical id, chromosome and locus, sequence length, OMA group, the relation type, an evolutionary distance and a score. A protein with no orthologs of that type returns an empty list. OMA release data, passed through unmodified and served by Eden Engine; not an official OMA product.

activeper callv1

Price

$0.0026 per call

You pay the price shown. If a call turns out to cost more than its quote, you pay the actual price, capped at twice the quote. No monthly minimum. Top-ups start at $0.50.

Data source

OMA Browser

Data from the OMA Browser (omabrowser.org), the Orthologous MAtrix orthology database. Credit to OMA is given as a courtesy. Served by Eden Engine; not an official OMA product.

Use it

Five steps: search, inspect, learn, run, settle. No per-tool setup; your agent reaches this tool through the meta-tools it already has.

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agent

// 1. search: find the tool
omnial_search({ query: "what you need" })

// 2. inspect: price and input schema
omnial_inspect({ tool: "omabrowser/orthologs" })

// 3. learn: read the usage guide at runtime
omnial_learn({ tool: "omabrowser/orthologs" })

// 4. run: price the exact call first, then run it
omnial_execute({ tool: "omabrowser/orthologs", input: { /* see input_schema */ }, dry_run: true })
omnial_execute({ tool: "omabrowser/orthologs", input: { /* ... */ } })

// 5. settle: the call is charged when it finishes, nothing to do

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Pricing

Every charge this tool can incur.

Charge	Price
Per call	$0.0026

Updated: Oct 21, 2026

Input and output schemas

Input schema

input_schema.json

{
  "type": "object",
  "required": [
    "id",
    "rel_type"
  ],
  "properties": {
    "id": {
      "type": "string",
      "pattern": "^(?!\\.\\.?$)[A-Za-z0-9_.-]{2,40}$",
      "description": "Protein identifier: a UniProt entry name such as P53_HUMAN, a UniProt accession such as P04637, or an OMA id such as HUMAN31534. Case matters for entry names."
    },
    "rel_type": {
      "enum": [
        "1:1",
        "1:n",
        "m:1",
        "m:n"
      ],
      "type": "string",
      "description": "Relation type to return. 1:1 is a single ortholog in the other species, 1:n and m:1 are one-to-many and many-to-one, m:n is many-to-many. Required: the unfiltered list of a conserved gene is over a megabyte."
    }
  },
  "additionalProperties": false
}

Output schema

output_schema.json

{
  "type": "object",
  "required": [
    "results"
  ],
  "properties": {
    "results": {
      "type": "array",
      "items": {
        "type": "object",
        "properties": {
          "locus": {
            "type": "object",
            "description": "start, end and strand on the chromosome.",
            "additionalProperties": true
          },
          "omaid": {
            "type": "string",
            "description": "OMA identifier, species code plus number."
          },
          "score": {
            "type": [
              "number",
              "null"
            ]
          },
          "species": {
            "type": "object",
            "description": "The species: `code` (OMA five-letter code), `taxon_id` (NCBI), `species` (scientific name), `genome_url`.",
            "additionalProperties": true
          },
          "distance": {
            "type": [
              "number",
              "null"
            ],
            "description": "Evolutionary distance in PAM units."
          },
          "entry_nr": {
            "type": "integer"
          },
          "rel_type": {
            "type": "string",
            "description": "1:1, 1:n, m:1 or m:n."
          },
          "entry_url": {
            "type": "string"
          },
          "oma_group": {
            "type": "integer",
            "description": "OMA group number; 0 when the protein is in no group."
          },
          "chromosome": {
            "type": [
              "string",
              "null"
            ]
          },
          "oma_hog_id": {
            "type": [
              "string",
              "null"
            ]
          },
          "canonicalid": {
            "type": "string",
            "description": "The protein's canonical external id, usually a UniProt accession or entry name."
          },
          "sequence_md5": {
            "type": "string"
          },
          "is_main_isoform": {
            "type": "boolean"
          },
          "sequence_length": {
            "type": "integer"
          }
        },
        "additionalProperties": true
      },
      "description": "One entry per ortholog, empty when the protein has none of that relation type."
    }
  },
  "additionalProperties": true
}