Biochemical Reaction Search by Compound or Keyword (Rhea)

rhea/search-reactions

Searches the Rhea database of expert-curated biochemical reactions for a compound name or other keyword that appears in the reaction equation, ignoring case. Returns each matching reaction's Rhea id (without the RHEA: prefix), plain-text equation, curation status, and balanced and transport flags, in id order, paged with limit and offset. A query that matches nothing returns an empty list. Up to 100 reactions per call. Rhea data under CC BY 4.0, served by Eden Engine; not an official Rhea or SIB product.

activeper callv2

Price

$0.0026 per call

You pay the price shown. If a call turns out to cost more than its quote, you pay the actual price, capped at twice the quote. No monthly minimum. Top-ups start at $5.

Data source

Rhea

Data from Rhea, the expert-curated biochemical reaction database of the SIB Swiss Institute of Bioinformatics (rhea-db.org), licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/); changes: reaction rows selected from the SPARQL result set and reshaped into flat objects. Credit: Rhea (rhea-db.org). Served by Eden Engine; not an official Rhea or SIB product.

Use it

Five steps: search, inspect, learn, run, settle. No per-tool setup; your agent reaches this tool through the meta-tools it already has.

Connect once and your AI can find and run this tool, and any other it needs.

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agent

// 1. search: find the tool
omnial_search({ query: "what you need" })

// 2. inspect: price and input schema
omnial_inspect({ tool: "rhea/search-reactions" })

// 3. learn: read the usage guide at runtime
omnial_learn({ tool: "rhea/search-reactions" })

// 4. run: price the exact call first, then run it
omnial_execute({ tool: "rhea/search-reactions", input: { /* see input_schema */ }, dry_run: true })
omnial_execute({ tool: "rhea/search-reactions", input: { /* ... */ } })

// 5. settle: the call is charged when it finishes, nothing to do

Not connected yet? Point your MCP client at https://mcp.eden-engine.com/mcp, then copy a config for your client.

Pricing

Every charge this tool can incur.

Charge	Price
Per call	$0.0026

Updated: Oct 21, 2026

Input and output schemas

Input schema

input_schema.json

{
  "type": "object",
  "required": [
    "query",
    "limit"
  ],
  "properties": {
    "limit": {
      "type": "integer",
      "maximum": 100,
      "minimum": 1,
      "description": "Maximum number of reactions to return, 1 to 100. Required: a broad query matches thousands of reactions."
    },
    "query": {
      "type": "string",
      "pattern": "^(?=.*[A-Za-z0-9])[A-Za-z0-9 .,+'()/_-]+$",
      "maxLength": 100,
      "minLength": 1,
      "description": "Text to find in the reaction equation, ignoring case: a compound name such as caffeine or NADPH, or a fragment of one. It is matched as one literal piece of text, as written, so write NADP(+) the way Rhea does and not NADP+. Letters, digits, spaces and . , + ' ( ) / _ - only, with at least one letter or digit."
    },
    "offset": {
      "type": "integer",
      "default": 0,
      "minimum": 0,
      "description": "Number of reactions to skip, for paging. Leave out for the first page."
    }
  },
  "additionalProperties": false
}

Output schema

output_schema.json

{
  "type": "object",
  "required": [
    "results"
  ],
  "properties": {
    "results": {
      "type": "array",
      "items": {
        "type": "object",
        "required": [
          "id",
          "equation"
        ],
        "properties": {
          "id": {
            "type": "string",
            "description": "Rhea reaction id without the RHEA: prefix, for example 17061."
          },
          "status": {
            "type": "string",
            "description": "Curation status, for example approved."
          },
          "comment": {
            "type": "string",
            "description": "Curator comment, often empty."
          },
          "balanced": {
            "type": "boolean",
            "description": "Whether the reaction is atom- and charge-balanced."
          },
          "equation": {
            "type": "string",
            "description": "Plain-text reaction equation, substrates = products."
          },
          "transport": {
            "type": "boolean",
            "description": "Whether the reaction is a transport reaction."
          },
          "htmlequation": {
            "type": "string",
            "description": "The equation as HTML markup with compound links; escape or sanitise before rendering."
          }
        },
        "additionalProperties": true
      },
      "description": "Rhea reactions, in the order Rhea returns them. Empty when nothing matches."
    }
  },
  "description": "The matching reactions, as a results list (empty when nothing matches).",
  "additionalProperties": true
}