UniProt Protein Search (Find UniProtKB Entries by Gene, Name or Organism)

uniprotrest/search-proteins

Searches the UniProt Knowledgebase (UniProtKB) with a UniProt query, for example gene_exact:BRCA1 AND organism_id:9606 AND reviewed:true, and returns up to 25 matching protein entries limited to the fields you choose: accession, entry id, gene names, protein name, organism and sequence length by default. Each entry keeps UniProt's nested structure. A query that matches nothing returns an empty list. First page only. UniProt data (CC BY 4.0), passed through unmodified and served by Eden Engine; not an official UniProt product.

activeper callv1

Price

$0.0026 per call

You pay the price shown. If a call turns out to cost more than its quote, you pay the actual price, capped at twice the quote. No monthly minimum. Top-ups start at $5.

Data source

UniProt Consortium

Data from UniProt (UniProt Consortium), licensed under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). Served by Eden Engine; not an official UniProt product.

Use it

Five steps: search, inspect, learn, run, settle. No per-tool setup; your agent reaches this tool through the meta-tools it already has.

Connect once and your AI can find and run this tool, and any other it needs.

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agent

// 1. search: find the tool
omnial_search({ query: "what you need" })

// 2. inspect: price and input schema
omnial_inspect({ tool: "uniprotrest/search-proteins" })

// 3. learn: read the usage guide at runtime
omnial_learn({ tool: "uniprotrest/search-proteins" })

// 4. run: price the exact call first, then run it
omnial_execute({ tool: "uniprotrest/search-proteins", input: { /* see input_schema */ }, dry_run: true })
omnial_execute({ tool: "uniprotrest/search-proteins", input: { /* ... */ } })

// 5. settle: the call is charged when it finishes, nothing to do

Not connected yet? Point your MCP client at https://mcp.eden-engine.com/mcp, then copy a config for your client.

Pricing

Every charge this tool can incur.

Charge	Price
Per call	$0.0026

Updated: Oct 20, 2026

Input and output schemas

Input schema

input_schema.json

{
  "type": "object",
  "required": [
    "query"
  ],
  "properties": {
    "size": {
      "type": "integer",
      "default": 10,
      "maximum": 25,
      "minimum": 1,
      "description": "How many entries to return, 1 to 25. Defaults to 10."
    },
    "query": {
      "type": "string",
      "maxLength": 500,
      "minLength": 1,
      "description": "UniProt search query, Lucene-like, with AND, OR, NOT and field:value terms, for example gene_exact:BRCA1 AND organism_id:9606 AND reviewed:true. organism_id takes an NCBI taxon id (9606 is human); reviewed:true keeps curated Swiss-Prot entries only."
    },
    "fields": {
      "type": "string",
      "default": "accession,id,gene_names,protein_name,organism_name,length",
      "pattern": "^[a-z0-9_]+(,[a-z0-9_]+){0,19}$",
      "description": "Comma-separated UniProt return fields, no spaces, for example accession,id,gene_names,protein_name,organism_name,length,cc_function. Keep the list short: a full entry is large."
    }
  },
  "additionalProperties": false
}

Output schema

output_schema.json

{
  "type": "object",
  "required": [
    "results"
  ],
  "properties": {
    "results": {
      "type": "array",
      "items": {
        "type": "object",
        "properties": {
          "genes": {
            "type": "array",
            "items": {
              "type": "object",
              "additionalProperties": true
            },
            "description": "Each has geneName.value and optional synonyms."
          },
          "organism": {
            "type": "object",
            "description": "scientificName, commonName, taxonId and lineage.",
            "additionalProperties": true
          },
          "sequence": {
            "type": "object",
            "description": "`length` is the sequence length in amino acids.",
            "additionalProperties": true
          },
          "entryType": {
            "type": "string",
            "description": "For example 'UniProtKB reviewed (Swiss-Prot)'."
          },
          "uniProtkbId": {
            "type": "string",
            "description": "The entry name, for example BRCA1_HUMAN."
          },
          "extraAttributes": {
            "type": "object",
            "additionalProperties": true
          },
          "primaryAccession": {
            "type": "string",
            "description": "The UniProtKB accession, for example P38398."
          },
          "proteinDescription": {
            "type": "object",
            "description": "recommendedName and alternativeNames, each with a fullName.value.",
            "additionalProperties": true
          }
        },
        "additionalProperties": true
      },
      "description": "Matching entries, each limited to the requested fields but keeping UniProt's nested structure."
    }
  },
  "description": "The matching UniProtKB entries. `results` is empty when the query matches nothing.",
  "additionalProperties": true
}